
Wilson wrote the 1992 animated short Diner. The goal is to collect 13 keys in 13 hours from the 13 rooms of a house by interacting in various ways with characters (for example, a two-headed monster, a mad scientist, and a vampiress), objects, and the house itself. Wilson created a computer game, Gahan Wilson's The Ultimate Haunted House, with Byron Preiss.

He has contributed short stories to other publications as well "M1" and "The Zombie Butler" both appeared in The Magazine of Fantasy & Science Fiction and were reprinted in Gahan Wilson's Cracked Cosmos (1975).

The "title" is a black blob, and the story is about an ominous black blob that appears on the page, growing at an alarming rate. Wilson wrote and illustrated a short story for Harlan Ellison's anthology Again, Dangerous Visions (1972). His hero, The Kid, sees the world as dark, dangerous and unfair-but also occasionally a fun place. His comic strip Nuts, which appeared in National Lampoon, was a reaction against what he saw as the saccharine view of childhood in strips like Peanuts.

He has been a movie review columnist for The Twilight Zone Magazine and a book critic for Realms of Fantasy magazine. From 1992 through end of publication, he prepared all the front covers for the annual book Passport to World Band Radio. In addition to his cartoons for The Magazine of Fantasy & Science Fiction, he also wrote movie and book reviews for that publication.

His cartoons and prose fiction appeared regularly in Playboy, Collier's and The New Yorker for almost 50 years. Wilson was inspired by the irreverent work of the various satiric Mad and Punch cartoonists, as well as the science fiction monster films of the 1950s. But while both feature vampires, cemeteries and other traditional horror elements in their work, Wilson's work has a more contemporary, shocking aspect to its humor, featuring atomic mutants, subway monsters and serial killers. Wilson's cartoons and illustrations are drawn in a playfully grotesque style and have a dark humor that is often compared to the work of The New Yorker cartoonist and Addams Family creator Charles Addams.
